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Polylactide acid (PLA), as an FDA-approved biomaterial,

has been widely applied due to its unique merits, such as its biocompatibility, biodegradability, and piezoelectricity.1)

1) Farahani A, Zarei-Hanzaki A, Abedi HR, Tayebi L, Mostafavi E. Polylactic acid piezo-biopolymers: chemistry, structural evolution, fabrication methods, and tissue
engineering applications. J Funct Biomater. 2021;12:71. p.1. doi:10.3390/jfb12040071.(CC BY 4.0)
URL: https://www.mdpi.com/2079-4983/12/4/71

Polymeric Structure Molecular Micro-Tuning - PSMMT
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DR. Moon Seok Shin, Dermatology
Optimal formulation
for skin regeneration activation
  • PLLA
  • CMC
    Moreover, in parenteral suspension injection, thixotropic fluid (CMC) plays an essential role in making the injection feel comfortable and accessible through the skin.
    : Rahman MS, Hasan MS, Nitai AS, Nam S, Karmakar AK, Ahsan MS, Shiddiky MJA, Ahmed MB. Recent developments of carboxymethyl cellulose. Polymers. 2021;13:1345. p.7. doi:10.3390/polym13081345. (CC BY 4.0)
    URL: https://www.mdpi.com/2073-4360/13/8/1345
  • Mannitol
    In addition, the chemical characteristics of mannitol make it as an antioxidant of choice in combination with HA, particularly because of its hydro-solubility compared with other antioxidants such as vitamin E which is lipid soluble, or 𝛽-caroten which is insoluble in water.
    : Rinaudo M, Lardy B, Grange L, Conrozier T. Effect of mannitol on hyaluronic acid stability in two in vitro models of oxidative stress. Polymers. 2014;6:1948-1957. p.8. doi:10.3390/polym6071948. (CC BY 4.0)
    URL: https://www.mdpi.com/2073-4360/6/7/1948
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